SAR 444727

Atuzabrutinib (SAR 444727) is a potent, selective reversible inhibitor of Btk (Bruton's tyrosine kinase) inhibitor. Atuzabrutinib inhibits neutrophil recruitment via inhibition of macrophage antigen-1 signalling .


Cat. No.: EX-A8599	Purity: >98%

	Chemical structure of SAR 444727

For research only, Do not use for Human!

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Synonyms	Atuzabrutinib
Synonyms 2	PRN473
CAS No.	1581714-49-9
Purity	>98%
Formula	C30H30FN7O2
Mol Weight	539.6033

Reference:	[1]. Herter JM, et al. PRN473, an inhibitor of Bruton's tyrosine kinase, inhibits neutrophil recruitment via inhibition of macrophage antigen-1 signalling. Br J Pharmacol. 2018;175(3):429-439.
CoA	CoA of SAR 444727

Smiles:	NC1=C2C(N([C@H]3CN(CCC3)C(/C(C#N)=C/C(C)(C)C)=O)N=C2C4=C(C=C(C=C4)OC5=CC=CC=C5)F)=NC=N1


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